Efficacy of Amniotic Membrane-Mesenchymal Stem Cell Therapy for Burn wounds: Metaanalysis study

Background : Burn injury is a trauma with high morbidity and mortality that requires special management from the start. stem cells have generated great hopes for treatment of numerous conditions including burns. The Metaanalysis was performed these preclinical studies to assess efficacy possible mechanisms Amniotic Membrane Mesenchymal Stem Cell (AM-MSC) in treating burn wounds.Methods: . Seven identified by searching PubMed, MEDLINE, databases inception October 2020. In addition, manual search references obtain potential studies. Stata 16 used all data analysis.Results overall meta-analysis showed AM-MSC therapy significantly improved healing rate (SMD 3.34, 95% CI 1.82 4.86), irrespective transplant type, area, method control groupConclusions: exerts appears exert positive effect wound healing, mainly through angiogenesis anti-inflammatory actions. There is, therefore, justification continued efforts evaluate variations future clinical using treat order maximize effectiveness. use as an adjunct first-line therapies